The Registry of Toxic Effects of Chemical Substances

Phosphoric acid, tri - o - tolyl ester

RTECS #: TD0350000

CAS #: 78-30-8

UPDATE: September 2000 MW: 368.39 MF: C21H21O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. o - Cresyl phosphate
  2. Phosflex 179C
  3. Phosphoric acid, tri - o - cresyl ester
  4. Phosphoric acid, tris (2 - methylphenyl) ester
  5. TOCP
  6. TOFK
  7. o - Tolyl phosphate
  8. Tri - o - cresyl phosphate
  9. o - Trikresylphosphate (German)
  1. Tri 2 - methylphenyl phosphate
  2. Triorthocresyl phosphate (ACGIH:OSHA)
  3. Tris (o - cresyl) - phosphate
  4. Tris (o - methylphenyl) phosphate
  5. Tris (o - tolyl) - phosphate
  6. Tri - o - tolyl phosphate
  7. Tri - 2 - tolyl phosphate
  8. Trojkrezylu fosforan (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage oral
rat 		500 mg/kg/10 day- continuous CRNGDP 14,2039,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,500 mg/kg (10 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 89,64,1987
oral
rat 		lowest published toxic dose: 2,100 mg/kg (14 day pregnant) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 107,35,1991
oral
rat 		lowest published toxic dose: 450 mg/kg (3 day male) Reproductive: Other effects on male TXAPA9 89,64,1987
oral
rat 		lowest published toxic dose: 3,150 mg/kg (21 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 89,64,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rabbit 		lowest published lethal dose: 135 mg/kg N/R AEPPAE 171,439,1933
intraperitoneal
chicken 		lethal dose (50 percent kill): 500 mg/kg N/R EQSFAP 3,173,1974
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,960 mg/kg N/R TXAPA9 2,495,1960
intraperitoneal
rat 		lethal dose (50 percent kill): 2,500 mg/kg N/R APCRAW 4,117,1961
intraperitoneal
rabbit 		lowest published lethal dose: 100 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes 		AEPPAE 168,473,1932
intravenous
rabbit 		lowest published lethal dose: 100 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Kidney, Ureter, and Bladder: Other changes in urine composition 		AEPPAE 168,473,1932
oral
chicken 		lethal dose (50 percent kill): 500 mg/kg N/R EQSFAP 3,173,1974
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 400 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 900 mg/kg Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair

Behavioral: Muscle weakness 		TXAPA9 7,227,1965
oral
rat 		lethal dose (50 percent kill): 1,160 mg/kg N/R TOXID9 4,55,1984
oral
rabbit 		lowest published lethal dose: 100 mg/kg Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Interstitial nephritis 		AEPPAE 168,473,1932
subcutaneous
cat 		lowest published lethal dose: 185 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		JHHBAI 52,39,1933
subcutaneous
dog 		lowest published lethal dose: 100 mg/kg Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Interstitial nephritis 		AEPPAE 168,473,1932
subcutaneous
guinea pig 		lowest published lethal dose: 300 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Musculoskeletal: Other changes 		AEPPAE 168,473,1932
subcutaneous
monkey 		lowest published lethal dose: 1 gm/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea 		AEPPAE 165,84,1972
subcutaneous
mouse 		lowest published lethal dose: 12,500 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		EDWU** -,-,1937
subcutaneous
rabbit 		lowest published lethal dose: 100 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes in urine composition 		AEPPAE 168,473,1932
skin
cat 		lethal dose (50 percent kill): 1,500 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea 		NTOTDY 5,431,1983
skin
rabbit 		lethal dose (50 percent kill): >3,700 mg/kg N/R TXAPA9 41,291,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 7 gm/kg/7 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases 		JEPOEC 17,69,1998
intraperitoneal
rat 		lowest published toxic dose: 2,800 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		DTESD7 11,495,1983
oral
chicken 		lowest published toxic dose: 1,800 mg/kg/18 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight 		TOLED5 37,279,1987
oral
chicken 		lowest published toxic dose: 1,050 mg/kg/14 day- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia 		TOXID9 42,126,1998
oral
duck 		lowest published toxic dose: 3 gm/kg/30 day- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Ataxia 		JTEHD6 14,789,1984
oral
domestic animal 		lowest published toxic dose: 900 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 69,417,1983
oral
mouse 		lowest published toxic dose: 4,725 mg/kg/21 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOLED5 18(Suppl 1),4,1983
oral
mouse 		lowest published toxic dose: 60,750 mg/kg/39 week- intermittent Spinal Cord: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia 		TXAPA9 79,83,1985
oral
rat 		lowest published toxic dose: 18,900 mg/kg/9 week- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count 		TOLED5 13,29,1982
oral
rabbit 		lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Autonomic Nervous System: Other (direct) parasympathomimetic 		TXAPA9 41,291,1977
subcutaneous
domestic bird 		lowest published toxic dose: 2,250 mg/kg/5 day- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Ataxia

Blood: Other changes 		NEZAAQ 47,222,1992
skin
domestic bird 		lowest published toxic dose: 6 gm/kg/10 day- intermittent Spinal Cord: Other degenerative changes NEZAAQ 52,281,1997
skin
cat 		lowest published toxic dose: 900 mg/kg/90 day- intermittent Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 83,126,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
CRTXB2 3,289,1975
TOXICOLOGY REVIEW
IRXPAT 3,219,1964
TOXICOLOGY REVIEW
CRTXB2 2,365,1973
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
ARENAA 26,29,1981


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 DTLVS* 3,271,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, short term exposure limit 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.3 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.1 mg/m3, short term exposure limit 0.3 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIORTHOCRESYL PHOSPHATE-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74600;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 14
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74600;
Number of Industries 1;
Total Number of Facilities 20;
Number of Occupations 1;
Total Number of Employees Exposed 20;
Total Number of Female Employees Exposed 20


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000
NIOSH Analytical Method, 1994: Triorthocresyl phosphate, 5037


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.)V.110-253, 1925-66. For publisher information, see NSAPCC.
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
ARENAA Annual Review of Entomology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1956-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87. Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EDWU** "Beitrag zur Toxikologie Technischer Weichmachungsmittel, Dissertation," Eller, H., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1937
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IRXPAT International Review of Experimental Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JHHBAI Bulletin of the Johns Hopkins Hospital. (Baltimore, MD) V.1-119, 1889-1966. For publisher information, see JHMJAX.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisherinformation, see NETEEC.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)V.1- 1959-



Used in hydraulic fluids and as plasticizer, pigment dispersant, flame retardant

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector

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