The Registry of Toxic Effects of Chemical Substances
Phenethyl alcohol RTECS #: SG7175000
CAS #: 60-12-8
The Registry of Toxic Effects of Chemical Substances
Phenethyl alcohol |
| UPDATE: October 1997 | MW: 122.18 | MF: C8H10O |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
12 gm/10 minute
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mild
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ARZNAD 9,349,1959
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eye | rabbit
750 µg/24 hour
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severe
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85JCAE -,215,1986
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skin | guinea pig
1,00%
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mild
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FCTXAV 13,903,1975
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skin | guinea pig
100 mg/24 hour
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moderate
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CTOIDG 94(8),41,1979
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skin | rabbit
100 mg/24 hour
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moderate
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CTOIDG 94(8),41,1979
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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mutation in microorganisms
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Saccharomyes cerevisiae
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1,000 ppm (-enzymatic activation step)
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GENRA8 13,107,1969
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other mutation test systems
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mouse
Ascites tumor
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8,360 µmol/L
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BCPCA6 22,2511,1973
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 43 mg/kg (6-15 day pregnant)
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Reproductive: Specific developmental abnormalities: Eye, ear | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JTEHD6 12,235,1983
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oral | rat
lowest published toxic dose: 430 mg/kg (6-15 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetal death | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system
JTEHD6 12,235,1983
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skin | rat
lowest published toxic dose: 14 gm/kg (6-15 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other developmental abnormalities
EPASR* 8EHQ-0186-0587
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skin | rat
lowest published toxic dose: 4,300 mg/kg (6-15 day pregnant)
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Reproductive: Specific developmental abnormalities: Musculoskeletal system
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EPASR* 8EHQ-0186-0587
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lethal concentration (50 percent kill): >500 mg/m3
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Behavioral: Somnolence (general depressed activity) | Blood: Normocytic anemia Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 52(10),83,1987
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intraperitoneal | guinea pig
lethal dose (50 percent kill): 200 mg/kg
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N/R
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38MKAJ 2C,4642,1982
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oral | guinea pig
lethal dose (50 percent kill): 2,540 mg/kg
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N/R
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VPITAR 33(5),48,1974
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oral | mouse
lethal dose (50 percent kill): 2,540 mg/kg
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N/R
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VPITAR 33(5),48,1974
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oral | rat
lethal dose (50 percent kill): 1,790 mg/kg
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Behavioral: Coma | Gastrointestinal: Gastritis
FCTXAV 2,327,1964
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oral | rabbit
lowest published lethal dose: 2 gm/kg
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N/R
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JEENAI 48,139,1955
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subcutaneous | mouse
lowest published lethal dose: 1,640 mg/kg
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Behavioral: General anesthetic | Behavioral: Ataxia Behavioral: Coma
JPETAB 14,211,1920
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skin | rabbit
lethal dose (50 percent kill): 790 µL/kg
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N/R
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TXAPA9 28,313,1974
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 6 gm/kg/30 day- intermittent
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Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 50(2),70,1985
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oral | rat
lowest published toxic dose: 6,052 mg/kg/17 week- intermittent
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Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VPITAR 33(5),48,1974
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 80836; | Number of Industries 22; Total Number of Facilities 873; Number of Occupations 41; Total Number of Employees Exposed 34,310
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 80836; |
Number of Industries 44; Total Number of Facilities 10,505; Number of Occupations 77; Total Number of Employees Exposed 161,595; Total Number of Female Employees Exposed 92,702 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000
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REFERENCES:
CODEN
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REFERENCE
38MKAJ
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"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc.,
1978-82. Vol. 3 originally pub. in 1979; pub. as 2ndrev. ed. in 1985.
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85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986
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ARZNAD
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Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach
1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
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BCPCA6
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Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958-
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CTOIDG
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Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL
60189) V.91- 1976-
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EPASR*
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United States Environmental Protection Agency, Office of Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M
St., SW, Washington, DC 20460) History unknown.
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FCTXAV
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Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7.
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GENRA8
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Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New York,
NY 10022) V.1- 1960-
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GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
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JEENAI
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Journal of Economic Entomology. (Entomological Soc. of America, 4603
Calvert Rd., College Park, MD 20740) V.1- 1908-
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JPETAB
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Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
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JTEHD6
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Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025
Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
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TXAPA9
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Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First
St., Duluth, MN 55802)V.1- 1959-
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VPITAR
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Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952-
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