The Registry of Toxic Effects of Chemical Substances (RTECS)

The Registry of Toxic Effects of Chemical Substances

Nicotine, sulfate (2:1)

RTECS #: QS9625000

CAS #: 65-30-5

UPDATE: July 2000 MW: 420.58 MF: C₂₀H₂₈N₄笧₄S

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

STANDARDS AND REGULATIONS:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

ENT 2,435

l - 1 - Methyl - 2 - (3 - pyridyl) - pyrrolidine sulfate

(S) - 3 - (1 - Methyl - 2 - pyrrolidinyl) pyridine sulfate (2:1)

l - 3 - (1 - Methyl - 2 - pyrrolidyl) pyridine sulfate

Nicotine sulfate

Nikotinsulfat (German)

Pyridine, 3 - (1 - methyl - 2 - pyrrolidinyl) - , (S) - , sulfate (2:1)

Pyrrolidine, 1 - methyl - 2 - (3 - pyridyl) - , sulfate

Sulfate de nicotine (French)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 1,670 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) BSTME2 3,31,1990/1991

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lethal concentration (50 percent kill): 22 mg/m³ N/R 85GMAT -,86,1982
intraperitoneal
cat lethal dose (50 percent kill): 20 mg/kg N/R 85GMAT -,86,1982
intraperitoneal
mouse lethal dose (50 percent kill): 10,200 痢/kg N/R JPPMAB 38,54,1986
intraperitoneal
rat lethal dose (90 percent kill): 29 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold NURIBL 23,43,1981
oral
wild bird lethal dose (50 percent kill): 32 mg/kg N/R TXAPA9 21,315,1972
oral
duck lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
mouse lethal dose (50 percent kill): 8,550 痢/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea HYSAAV 34(4-6),187,1969
oral
pigeon lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
quail lethal dose (50 percent kill): 316 mg/kg N/R AECTCV 12,355,1983
oral
rat lethal dose (50 percent kill): 50 mg/kg N/R ARSIM* 20,16,1966
skin
rat lethal dose (50 percent kill): 285 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement TXAPA9 2,88,1960
skin
rabbit lethal dose (50 percent kill): 50 mg/kg N/R 85GYAV -,141,1971

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 571 mg/kg/8 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 34(5),30,1969

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m³, JAN1993

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000

REFERENCES:
CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
BSTME2 Biological Structures and Morphogenesis. (Paris, Francs) V.1- 1988-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
NURIBL Nutrition Reports International. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)V.1- 1959-

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

SKC Gulf Coast Home   NIOSH Database Home