The Registry of Toxic Effects of Chemical Substances

Lactic acid

RTECS #: OD2800000

CAS #: 50-21-5

UPDATE: March 2000 MW: 90.09 MF: C3H6O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Ethylidenelactic acid
  2. 1 - Hydroxyethanecarboxylic acid
  3. 2 - Hydroxypropanoic acid
  4. 2 - Hydroxypropionic acid
  5. alpha - Hydroxypropionic acid
  6. Kyselina 2 - hydroxypropanova (Czech)
  7. Kyselina mlecna (Czech)
  8. DL - Lactic acid
  1. Milchsaure (German)
  2. Milk acid
  3. Ordinary lactic acid
  4. Propanoic acid, 2 - hydroxy -
  5. Propel
  6. Propionic acid, 2 - hydroxy -
  7. Racemic lactic acid
  8. SY - 83


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		750 µg severe AJOPAA 29,1363,1946
skin
rabbit 		5 mg/24 hour severe 85JCAE -,656,1986
skin
rabbit 		100 mg/24 hour moderate IJTOFN 17(Suppl 1),71,1998


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 10 mmol/L MUREAV 240,195,1990
mutation in microorganisms Escherichia coli 210 ppm/3 hour (-enzymatic activation step) AMNTA4 85,119,1951


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5,700 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		RCOCB8 77,95,1992


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lethal dose (50 percent kill): 1,810 mg/kg N/R JIHTAB 23,259,1941
oral
mouse 		lethal dose (50 percent kill): 4,875 mg/kg N/R FAONAU 40,144,1967
oral
quail 		lethal dose (50 percent kill): >2,250 mg/kg N/R FMCHA2 -,C252,1991
oral
rat 		lethal dose (50 percent kill): 3,543 mg/kg N/R FMCHA2 -,C252,1991
oral
rabbit 		lowest published lethal dose: 5 gm/kg N/R IECHAD 15,628,1923
rectal
rabbit 		lowest published lethal dose: 600 mg/kg N/R CRSBAW 83,136,1920
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R FMCHA2 -,C252,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rat 		lowest published toxic dose: 57,590 mg/kg/13 week- intermittent Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Other changes 		IJTOFN 17(Suppl 1),71,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80595;
Number of Industries 56;
Total Number of Facilities 10,707;
Number of Occupations 50;
Total Number of Employees Exposed 68,982
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80595;
Number of Industries 39;
Total Number of Facilities 10,134;
Number of Occupations 58;
Total Number of Employees Exposed 107,962;
Total Number of Female Employees Exposed 63,436


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000
NTP Carcinogenesis studies; selected, April 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL.
IJTOFN
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966,Westbury, NY 11590) V.1- 1970-



Used as an antiseptic agent

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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