The Registry of Toxic Effects of Chemical Substances

Hydroperoxide, alpha,alpha - dimethylbenzyl -

RTECS #: MX2450000

CAS #: 80-15-9

UPDATE: September 2000 MW: 152.21 MF: C9H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Cumeenhydroperoxyde (Dutch)
  2. Cumene hydroperoxide
  3. Cumenyl hydroperoxide
  4. Cumolhydroperoxid (German)
  5. Cumyl hydroperoxide
  6. alpha - Cumyl hydroperoxide
  7. alpha,alpha - Dimethylbenzyl hydroperoxide
  8. Hydroperoxyde de cumene (French)
  1. Hydroperoxyde de cumyle (French)
  2. 7 - Hydroperoxykumen (Czech)
  3. Idroperossido di cumene (Italian)
  4. Idroperossido di cumolo (Italian)
  5. Isopropylbenzene hydroperoxide
  6. Kumenylhydroperoxid (Czech)
  7. RCRA waste number U096


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg N/R AIHAAP 19,205,1958
skin
rabbit 		500 mg N/R AIHAAP 19,205,1958
skin
rabbit 		500 mg mild SCCUR* -,3,1961


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test intraperitoneal
mouse 		750 µmol/kg/5 day- continuous MUREAV 444,145,1999
mutation in microorganisms Escherichia coli 12,500 ng/plate (-enzymatic activation step) MUREAV 467,41,2000
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) PNASA6 79,7445,1982
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) ABCHA6 44,1989,1980
gene conversion and mitotic recombination Saccharomyes cerevisiae 47 mg/L MUREAV 308,159,1994
other mutation test systems Escherichia coli 10 µmol/L MUREAV 203,81,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 8,844 mg/kg/67 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 37,825,1966
unreported route
mouse 		lowest published toxic dose: 304 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors 		RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 200 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
inhalation
rat 		lethal concentration (50 percent kill): 220 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
intraperitoneal
mouse 		lethal dose (50 percent kill): 270 mg/kg N/R GISAAA 26(12),22,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 95 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia 		AIHAAP 19,205,1958
oral
mouse 		lowest published lethal dose: 5 gm/kg N/R SCCUR* -,3,1961
oral
rat 		lethal dose (50 percent kill): 382 mg/kg Kidney, Ureter, and Bladder: Hematuria AIHAAP 19,205,1958
subcutaneous
mouse 		lethal dose (50 percent kill): 490 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 26(12),22,1961
subcutaneous
rat 		lethal dose (50 percent kill): 382 mg/kg N/R 85JCAE -,242,1986
skin
rat 		lethal dose (50 percent kill): 500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria 		AEHLAU 30,1,1975
skin
rabbit 		lowest published lethal dose: 1,200 mg/kg Cardiac: Pulse rate increased without fall in BP

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Body temperature decrease 		GTPZAB 8(8),12,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 50 ppm/4 hour/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BJIMAG 27,1,1970
intraperitoneal
rat 		lowest published toxic dose: 399 mg/kg/7 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 19,205,1958
oral
rat 		lowest published toxic dose: 1,604 mg/kg/7 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 19,205,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1346;
Number of Industries 80;
Total Number of Facilities 4,311;
Number of Occupations 53;
Total Number of Employees Exposed 95,676
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1346;
Number of Industries 125;
Total Number of Facilities 10,989;
Number of Occupations 85;
Total Number of Employees Exposed 234,305;
Total Number of Female Employees Exposed 69,933


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000
NTP Carcinogenesis studies; selected, April 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME04046) V.1- 1944-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)



Used as polymerization initiator, curing agent and cross-linking agent

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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