The Registry of Toxic Effects of Chemical Substances

Ethane, 1,1,1 - trichloro - 2,2 - bis (p - methoxyphenyl) -

RTECS #: KJ3675000

CAS #: 72-43-5

UPDATE: September 2000 MW: 345.66 MF: C16H15Cl3O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Benzene, 1,1' - (2,2,2 - trichloroethylidene) bis (4 - methoxy -
  2. 2,2 - Bis (p - anisyl) - 1,1,1 - trichloroethane
  3. 1,1 - Bis (p - methoxyphenyl) - 2,2,2 - trichloroethane
  4. 2,2 - Bis (p - methoxyphenyl) - 1,1,1 - trichloroethane
  5. Dianisyltrichlorethane
  6. 2,2 - Di - p - anisyl - 1,1,1 - trichloroethane
  7. Dimethoxy - DDT
  8. p,p' - Dimethoxydiphenyltrichloroethane
  9. 2,2 - Di - (p - methoxyphenyl) - 1,1,1 - trichloroethane
  10. Di (p - methoxyphenyl) - trichloromethyl methane
  11. DMDT
  12. p,p' - Dwumetoksydwufenylotrojchloroetan (Polish)
  13. ENT 1,716
  14. Ethane, 2,2 - bis (p - anisyl) - 1,1,1 - trichloro -
  15. Higalmetox
  16. Marlate
  17. Methoxcide
  18. Methoxychlor (ACGIH:OSHA)
  1. p,p' - Methoxychlor
  2. Methoxychlor 2 EC
  3. Methoxy - DDT
  4. Metoksychlor (Polish)
  5. Metox
  6. Mezox K
  7. Moxie
  8. NCI - C00497
  9. OMS 466
  10. RCRA waste number U247
  11. 1,1,1 - Trichlor - 2,2 - bis (4 - methoxy - phenyl) - aethan (German)
  12. 1,1,1 - Trichloro - 2,2 - bis (p - anisyl) ethane
  13. 1,1' - (2,2,2 - Trichloroethylidene) bis (4 - methoxybenzene)
  14. 1,1,1 - Trichloro - 2,2 - bis (p - methoxyphenyl) ethane
  15. 1,1,1 - Trichloro - 2,2 - bis (4 - methoxyphenyl) ethane
  16. 2,2,2 - Trichloro - 1,1 - bis (4 - methoxyphenyl) ethane
  17. 1,1,1 - Trichloro - 2,2 - di (4 - methoxyphenyl) ethane
  18. 4,4 - (2,2,2 - Trichloroethylidene) dianisole


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
hamster 		50 mg/kg ARTODN 58,152,1986
cytogenetic analysis oral
mouse 		6 mg/kg/50 day- intermittent FOMOAJ 35,361,1976
DNA damage rat liver 150 µmol/L EMMUEG 24,181,1994
mutation in microorganisms mouse lymphocyte 10 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
morphological transform hamster embryo 10 mg/L MUREAV 356,85,1996
morphological transform mouse fibroblast 2 mg/L JJIND8 67,1303,1981
sperm morphology oral
rat 		28 gm/kg/10 week- continuous PSEBAA 176,187,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 800 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		REPTED 11,703,1997
oral
mouse 		lowest published toxic dose: 1 gm/kg (20 day pregnant) Reproductive: Maternal effects: Ovaries, fallopian tubes REPTED 5,139,1991
oral
mouse 		lowest published toxic dose: 900 mg/kg (6-8 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 6,431,1992
oral
mouse 		lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Maternal effects: Parturition REPTED 6,431,1992
oral
mouse 		lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death REPTED 6,431,1992
oral
rat 		lowest published toxic dose: 66 gm/kg (33 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		JPETAB 138,126,1962
oral
rat 		lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TXAPA9 45,435,1978
oral
rat 		lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 45,435,1978
oral
rat 		lowest published toxic dose: 4,250 mg/kg (42 day prior to copulation-21 day after birth) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects 		JAFCAU 22,969,1974
oral
rat 		lowest published toxic dose: 10,625 mg/kg (42 day prior to copulation-21 day after birth) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) 		JAFCAU 22,969,1974
oral
rabbit 		lowest published toxic dose: 330 mg/kg (6-27 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		CGANE7 39,190,1999
subcutaneous
mouse 		lowest published toxic dose: 99 mg/kg (5-7 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral 		REPTED 13,405,1999
unreported route
rat 		lowest published toxic dose: 7 gm/kg (70 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) AHEMA5 9,89,1980
unreported route
rat 		lowest published toxic dose: 2,100 mg/kg (21 day prior to copulation) Reproductive: Maternal effects: Oogenesis AHEMA5 9,89,1980
unreported route
rat 		lowest published toxic dose: 9,100 mg/kg (70 day male/21 day prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) AHEMA5 9,89,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 383 gm/kg/3 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		EVHPAZ 36,205,1980
oral
mouse 		lowest published toxic dose: 56,700 mg/kg/90 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Testicular tumors 		JCROD7 93,173,1979
oral
mouse 		toxic dose : 62,622 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		EVHPAZ 36,205,1980
oral
rat 		lowest published toxic dose: 18,200 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Prostate tumors 		EVHPAZ 36,205,1980
oral
rat 		toxic dose : 41 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Multiple effects

Lung, Thorax, or Respiration: Other changes 		TXAPA9 11,88,1967
oral
rat 		toxic dose : 80 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Ovarian tumors 		LIFSAK 24,1367,1979
oral
rat 		toxic dose : 72,800 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		EVHPAZ 36,205,1980
oral
rat 		toxic dose : 87,360 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		EVHPAZ 36,205,1980
oral
rat 		toxic dose : 10,920 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		AIPTAK 83,491,1950
oral
rat 		toxic dose : 45,500 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		AIPTAK 83,491,1950


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
hamster 		lethal dose (50 percent kill): 500 mg/kg N/R ARTODN 58,152,1986
oral
duck 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,574,1991
oral
human 		lowest published lethal dose: 6,430 mg/kg N/R PCOC** -,705,1966
oral
mouse 		lethal dose (50 percent kill): 510 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Ataxia 		GISAAA 58(1),44,1993
oral
rat 		lethal dose (50 percent kill): 1,855 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Ataxia 		GISAAA 58(1),44,1993
oral
rabbit 		lethal dose (50 percent kill): >6 gm/kg N/R SPEADM 78-1,16,1978
skin
human 		lowest published toxic dose: 2,414 mg/kg Behavioral: Somnolence (general depressed activity) PCOC** -,705,1966
skin
rat 		lethal dose (50 percent kill): >6 gm/kg N/R CMEP** -,1,1956
skin
rabbit 		lethal dose (50 percent kill): >6 gm/kg N/R WRPCA2 3,28,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 266 mg/kg/19 week- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA 53(10),82,1988
oral
rat 		lowest published toxic dose: 602 mg/kg/43 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 58(1),44,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 20,259,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 20,259,1979
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
CTOXAO 13,231,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 DTLVS* 3,152,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 15 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 15 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 15 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 15 mg/m3, MAC(short term exposure limit) 45 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 10 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 10 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 10 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHOXYCHLOR-air Carcinogen (0.07 mg/m3 LOQ) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 46210;
Number of Industries 2;
Total Number of Facilities 248;
Number of Occupations 2;
Total Number of Employees Exposed 638
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 46210;
Number of Industries 2;
Total Number of Facilities 504;
Number of Occupations 2;
Total Number of Employees Exposed 3,417


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-35,1978


REFERENCES:

CODEN
REFERENCE
AHEMA5 Anatomia, Histologia, Embryologia. (Paul Parey Scientific Pub., 35 W. 38th St., Suite 3W, NewYork, NY 10018) V.2- 1973-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589Japan) V.27- 1987-
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)V.1- 1936-
FOMOAJ Folia Morphologica (Warsaw). (Panstwowy Zaklad Wydawnictw Lekarskich, ul. Dluga 38-40, 00 238Warsaw, Poland) V.1- 1929-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO PublicationsCentre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park,MD 20740)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.



Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

SKC Gulf Coast Home   NIOSH Database Home