The Registry of Toxic Effects of Chemical Substances

Anthranilic acid

RTECS #: CB2450000

CAS #: 118-92-3

UPDATE: April 1999 MW: 137.15 MF: C7H7NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. o - Aminobenzoic acid
  2. 2 - Aminobenzoic acid
  3. 1 - Amino - 2 - carboxybenzene
  4. o - Anthranilic acid
  5. Benzoic acid, o - amino -
  6. Carboxyaniline
  1. o - Carboxyaniline
  2. 2 - Carboxyaniline
  3. Kyselina o - aminobenzoova (Czech)
  4. Kyselina anthranilova (Czech)
  5. NCI - C01730
  6. Vitamin L


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms mouse lymphocyte 250 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),37,1988
mutation in mammalian somatic cells human lymphocyte 1,667 mg/L MUREAV 196,61,1988
mutation in mammalian somatic cells mouse lymphocyte 1,266 mg/L EMMUEG 12(Suppl 13),37,1988
sister chromatid exchange intraperitoneal
mouse 		600 mg/kg EMMUEG 14,207,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 34,800 mg/kg (8 day male/21 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) MPHEAE 15,7,1966


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 16 gm/kg/25 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		APMIAL 26,447,1949
subcutaneous
mouse 		lowest published toxic dose: 1,345 mg/kg/21 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Liver: Tumors 		JCROD7 96,163,1980
subcutaneous
mouse 		lowest published toxic dose: 2,040 mg/kg (13-17 day pregnant) Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Liver: Tumors 		JCROD7 96,163,1980


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,500 mg/kg N/R RPTOAN 37,105,1974
intravenous
mouse 		lethal dose (50 percent kill): >500 mg/kg N/R YKKZAJ 89,1392,1990
oral
wild bird 		lethal dose (50 percent kill): 750 mg/kg N/R AECTCV 12,355,1983
oral
mouse 		lethal dose (50 percent kill): 1,400 mg/kg N/R QJPPAL 19,483,1946
oral
rat 		lethal dose (50 percent kill): 5,410 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia 		GTPZAB 27(3),52,1983
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 6,310 mg/kg N/R GISAAA 48(6),22,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 16,265,1978
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 16,265,1978
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4427;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 28


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-36,1978


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
APMIAL Acta Pathologica et Microbiologica Scandinavica. (Copenhagen, Denmark) V.1-77, 1924-69. Forpublisher information, see ACPADQ.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO PublicationsCentre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979-
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-



Used in the production of dyes and pigments, and as raw material in SACCHARIN manufacture

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

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