The Registry of Toxic Effects of Chemical Substances

Ammonium, (2 - chloroethyl) trimethyl - , chloride

RTECS #: BP5250000

CAS #: 999-81-5

UPDATE: July 2000 MW: 158.09 MF: C5H13ClN•Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. AC 38555
  2. Antywylegacz
  3. Barleyquat B
  4. Bercema CCC
  5. CCC (plant growth regulant)
  6. 2 - Chloraethyl - trimethylammoniumchlorid (German)
  7. Chlorcholinchlorid (Czech)
  8. Chlorcholine chloride
  9. Chlormequat chloride
  10. Chlorocholine chloride
  11. (beta - Chloroethyl) trimethylammonium chloride
  12. (2 - Chloroethyl) trimethylammonium chloride
  13. 2 - Chloro - N,N,N - trimethylethanaminium chloride
  14. 60 - CS - 16
  15. Cycocel
  1. Cycocel Extra
  2. EI 38,555
  3. Ethanaminium, 2 - chloro - N,N,N - trimethyl - , chloride (9CI)
  4. Hico CCC
  5. Hormocel - 2CCC
  6. Increcel
  7. Lihocin
  8. NCI - C02960
  9. Premix
  10. Retacel
  11. Stabilan
  12. Trimethyl - beta - chlorethylammoniumchlorid (Czech)
  13. TUR
  14. WR 62
  15. Zar


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour mild 85JCAE -,616,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition intravaginal
mouse 		5 pph JIDEAE 62,378,1974
mutation in microorganisms Escherichia coli 500 mmol/L/30 minute (-enzymatic activation step) MUREAV 40,229,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 7,100 mg/kg/78 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >5,200 mg/m3/4 hour N/R PEMNDP 9,149,1991
intraperitoneal
mouse 		lethal dose (50 percent kill): 62 mg/kg N/R ABMGAJ 27,663,1971
intraperitoneal
rat 		lethal dose (50 percent kill): 64 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		ABMGAJ 33,89,1974
intravenous
cat 		lowest published lethal dose: 1,200 µg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
intravenous
human 		lowest published lethal dose: 1 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
intravenous
mouse 		lethal dose (50 percent kill): 7 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
intravenous
rat 		lethal dose (50 percent kill): 12,500 µg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
intravenous
rabbit 		lowest published lethal dose: 4 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
oral
domestic bird 		lethal dose (50 percent kill): 261 mg/kg N/R PEMNDP 9,149,1991
oral
cat 		lethal dose (50 percent kill): 7 mg/kg N/R AXVMAW 24,1049,1970
oral
chicken 		lethal dose (50 percent kill): 920 mg/kg N/R PEMNDP 9,149,1991
oral
dog 		lethal dose (50 percent kill): 50 mg/kg N/R AXVMAW 24,1049,1970
oral
human 		lowest published lethal dose: 10 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 670 mg/kg N/R GUCHAZ 6,104,1973
oral
mouse 		lethal dose (50 percent kill): 54 mg/kg N/R ABMGAJ 27,663,1971
oral
quail 		lethal dose (50 percent kill): 555 mg/kg N/R PEMNDP 9,149,1991
oral
rat 		lethal dose (50 percent kill): 600 mg/kg N/R GISAAA 36(11),33,1971
oral
rabbit 		lethal dose (50 percent kill): 70 mg/kg N/R AXVMAW 31,527,1977
skin
mammal (species unspecified) 		lethal dose (50 percent kill): 440 mg/kg N/R GUCHAZ 6,104,1973
skin
rat 		lethal dose (50 percent kill): >4 gm/kg N/R PEMNDP 9,149,1991
skin
rabbit 		lethal dose (50 percent kill): 232 mg/kg N/R WRPCA2 9,119,1970
unreported route
mouse 		lethal dose (50 percent kill): 560 mg/kg N/R VINIT* #4758-80
unreported route
rat 		lethal dose (50 percent kill): 780 mg/kg N/R VINIT* #4758-80


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,920 mg/kg/24 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response 		TXCYAC 30,103,1984
oral
rat 		lowest published toxic dose: 7,920 mg/kg/72 day- intermittent Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		GISAAA 36(11),33,1971
oral
rat 		lowest published toxic dose: 15,600 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		GISAAA 43(4),8,1978
oral
rabbit 		lowest published toxic dose: 1,092 mg/kg/39 week- intermittent Endocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight 		GISAAA 36(11),33,1971


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4610;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 2;
Total Number of Employees Exposed 107


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-158,1979


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisherinformation, see BBIADT.
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore,MD 21202) V.1- 1938-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications.
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.



Used as a solvent, emulsifier, agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 39394-21-3

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